Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myocarditis I: Introduction

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

Myocarditis III: Medical Management

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

Myocarditis IV: Nursing Management

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...

Layers of the Heart Wall

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...

Pericarditis I: Introduction

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Effects of High-Thoracic Spinal Cord Injury on the Heart Transcriptome.

Journal of neurotrauma·2026

Same author

Skin in the claim: United States patenting process and tips for dermatologists.

The Journal of investigative dermatology·2026

Same author

Bioinformatics strategies and biomarker refinement using high-throughput transcriptome data in transplantation.

Frontiers in bioinformatics·2026

Same author

Broad-spectrum bactericidal synergy of silver-cannabichromene-cannabigerol triple combinations against healthcare-associated pathogens.

Journal of applied microbiology·2026

Same author

Increased prevalence of esophageal squamous cell papilloma in eosinophilic esophagitis: incidental finding or disease related consequence?

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026

Same author

Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration.

Frontiers in immunology·2026

Search research articles

Related Experiment Video

Updated: May 26, 2026

Isolation and Identification of Extravascular Immune Cells of the Heart

Isolation and Identification of Extravascular Immune Cells of the Heart

Published on: August 23, 2018

Inflammation in myocardial diseases.

David J Marchant¹, John H Boyd, David C Lin

¹James Hogg Research Centre and Institute for Heart + Lung Health, Department of Pathology and Laboratory Medicine, University of British Columbia, Providence Health Care, Vancouver, Canada.

Circulation Research

|January 7, 2012

Summary

Inflammation injures heart muscle through various conditions like ischemia, sepsis, viral myocarditis, and immune rejection, involving shared inflammatory mechanisms with both good and bad outcomes.

More Related Videos

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Published on: August 16, 2019

Related Experiment Videos

Last Updated: May 26, 2026

Isolation and Identification of Extravascular Immune Cells of the Heart

Isolation and Identification of Extravascular Immune Cells of the Heart

Published on: August 23, 2018

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Published on: August 16, 2019

Area of Science:

Cardiology
Immunology
Pathology

Background:

Inflammatory processes are central to myocardial injury, leading to structural and functional heart deficits.
Understanding shared and unique inflammatory mechanisms is crucial for managing heart conditions.

Purpose of the Study:

To review current knowledge on four common forms of myocardial inflammation.
To examine shared inflammatory mechanisms in myocardial ischemia/reperfusion, sepsis, viral myocarditis, and immune rejection.

Main Methods:

Literature review of scientific articles on myocardial inflammation.
Analysis of cellular and soluble mediators involved in inflammatory responses.
Examination of pathogenesis and disease evolution in common cardiac inflammatory conditions.

Main Results:

Identified four key conditions causing myocardial inflammation: ischemia/reperfusion, sepsis, viral myocarditis, and immune rejection.
Highlighted shared inflammatory pathways across these diverse conditions.
Recognized both beneficial and detrimental roles of inflammation in myocardial injury.

Conclusions:

Myocardial inflammation stems from diverse triggers but involves common inflammatory pathways.
Immune responses, both innate and adaptive, play a significant role in disease progression.
Inflammation in the heart can have dual effects, necessitating targeted therapeutic strategies.