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Updated: May 26, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
Published on: December 18, 2020
Cilia in vertebrate development and disease
Edwin C Oh1, Nicholas Katsanis
1Center for Human Disease Modeling, Department of Cell Biology, Duke University, Durham NC 27710, USA. Edwin.oh@duke.edu
Abstract:
Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.
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