Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

Viral Hepatitis I: Introduction

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gastroesophageal reflux disease in a typical African population: a symptom-based multicenter study.

BMC gastroenterology·2020

Same author

Quantitative Platelet Abnormalities in Patients With Hepatitis B Virus-Related Liver Disease.

Gastroenterology research·2016

Same author

Relatively Long Survival in Hepatocellular Carcinoma Presenting With Carcinoid Syndrome.

Gastroenterology research·2016

Same author

Esophageal Intraepithelial Neutrophil Infiltration is Common in Nigerian Patients With Non-Erosive Reflux Disease.

Gastroenterology research·2016

Same author

Platelet Function and Other Indices of Hemostasis in Chronic Liver Disease.

Gastroenterology research·2016

Same author

Time trends of upper gastrointestinal diseases in Nigeria.

Annals of gastroenterology·2014

Search research articles

Related Experiment Video

Updated: May 26, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Chronic hepatitis B: management challenges in resource-poor countries.

Sylvester Chuks Nwokediuko¹

¹Department of Medicine, University of Nigeria, Teaching Hospital, Ituku Ozalla, Enugu, Nigeria. sylvester.nwokediuko@unn.edu.ng

Hepatitis Monthly

|January 7, 2012

Summary

Chronic hepatitis B virus (HBV) infection is a global health issue, especially in resource-limited areas. Addressing challenges like limited data, poor political will, and high costs is crucial for effective management and control of HBV.

Keywords:

Chronic Disease Management Hepatitis B Public Health

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Related Experiment Videos

Last Updated: May 26, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Area of Science:

Hepatology
Public Health
Infectious Diseases

Background:

Chronic hepatitis B virus (HBV) infection poses a significant global health challenge, with high prevalence in resource-limited regions.
Limited healthcare resources exacerbate the difficulties in managing HBV, leading to potential severe health consequences.

Purpose of the Study:

To highlight the multifaceted challenges in managing chronic HBV infection in resource-limited settings.
To emphasize the need for improved understanding, political commitment, and resource allocation for HBV control.

Main Methods:

This study is a review of existing literature and challenges in HBV management.
It synthesizes information on prevalence, diagnostic, and treatment barriers in resource-limited countries.

Main Results:

Key challenges include a lack of accurate data, inadequate surveillance, poor political will, and insufficient healthcare manpower.
High costs of diagnostics and drugs, patient stigmatization, co-infections, and lack of management guidelines further complicate HBV management.

Conclusions:

Effective management of chronic HBV requires increased government commitment, budgetary allocation, and public health initiatives.
International cooperation, improved healthcare infrastructure, and adherence to global policies are essential for controlling HBV in underserved populations.