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Related Experiment Video

Updated: May 26, 2026

Detecting Migration and Infiltration of Neutrophils in Mice

Detecting Migration and Infiltration of Neutrophils in Mice

Published on: February 6, 2020

Neutrophil function: from mechanisms to disease.

Borko Amulic¹, Christel Cazalet, Garret L Hayes

¹Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany. amulic@mpiib-berlin.mpg.de

Annual Review of Immunology

|January 10, 2012

Summary

Neutrophils, crucial white blood cells, are vital for immune defense but challenging to study. This review explores their roles beyond killing, highlighting their function as immune system instructors in disease.

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Area of Science:

Immunology
Cell Biology
Hematology

Background:

Neutrophils are the most abundant leukocytes, critical for host defense against infection.
Congenital neutrophil deficiencies lead to severe, often fatal infections.
Research on neutrophils is limited by their experimental intractability.

Purpose of the Study:

To provide a comprehensive survey of neutrophil biology.
To emphasize neutrophils' roles as both killers and immune instructors.
To address emerging issues and unanswered questions in neutrophil research.

Main Methods:

Literature review and critical analysis of existing research.
Focus on experimental data and common assumptions in neutrophil studies.
Synthesis of current knowledge on neutrophil function in immunity and disease.

Main Results:

Neutrophils act as professional killers and also instruct other immune cells.
Neutrophil functions extend to regulating inflammatory and infectious disease processes.
The review highlights key examples of neutrophils' multifaceted roles.

Conclusions:

Neutrophils are essential immune cells with complex functions beyond pathogen killing.
Further research is needed to overcome experimental challenges and fully understand neutrophil biology.
Understanding neutrophils is critical for developing treatments for immune deficiencies and inflammatory diseases.