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Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
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Published on: February 17, 2023

Microbial translocation across the GI tract.

Jason M Brenchley1, Daniel C Douek

  • 1Program in Barrier Immunity and Repair and Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA. jbrenchl@mail.nih.gov

Annual Review of Immunology
|January 10, 2012
PubMed
Summary
This summary is machine-generated.

The gastrointestinal microbiota plays a key role in health. This review discusses microbial translocation (MT), its link to diseases, and potential therapies to reduce MT.

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Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

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Published on: May 2, 2018

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • The gastrointestinal (GI) tract hosts a vast microbiota crucial for host health.
  • Maintaining a balance between the microbiota and the host immune system prevents excessive immune activation.
  • Dysregulation of this balance can lead to diseases associated with microbial translocation (MT).

Purpose of the Study:

  • To elucidate the mechanisms driving microbial translocation (MT).
  • To identify diseases linked to MT and its consequences.
  • To explore therapeutic strategies for mitigating MT.

Main Methods:

  • Review of existing literature on microbial translocation.
  • Analysis of immune system interactions with gut microbiota.
  • Examination of disease pathologies associated with MT.

Main Results:

  • Several host mechanisms have evolved to control microbial translocation.
  • Failure of these mechanisms leads to immune activation and disease.
  • MT is implicated in various pathologies affecting host health.

Conclusions:

  • Understanding MT mechanisms is vital for disease management.
  • Targeting MT offers potential therapeutic avenues.
  • Further research into MT and its clinical implications is warranted.