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Amyloidosis in Behçet's syndrome.
S Yurdakul1, N Tüzüner, I Yurdakul
1Department of Medicine (Division of Rheumatology and Gastroenterology), Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.
Arthritis and Rheumatism
|October 1, 1990
Summary
Systemic amyloidosis is rare in Behçet's syndrome patients. A study found only 5 cases of AA-type amyloidosis among 1,130 patients, with no amyloidosis detected in rectal biopsies of 99 patients.
Area of Science:
- Rheumatology
- Nephrology
- Pathology
Background:
- Behçet's syndrome is a chronic inflammatory disorder.
- Amyloidosis is a potential complication of chronic inflammation.
- The incidence of amyloidosis in Behçet's syndrome requires further investigation.
Purpose of the Study:
- To determine the frequency of amyloidosis in patients with Behçet's syndrome.
- To evaluate the utility of rectal biopsies in diagnosing amyloidosis in this population.
Main Methods:
- Retrospective analysis of 99 consecutive Behçet's syndrome patients.
- Rectal biopsies examined using polarizing microscopy.
- Urinalysis performed on all patients.
- Review of 1,130 patients in a Behçet's syndrome outpatient clinic registry.
Main Results:
- No amyloidosis was detected in rectal biopsies of the 99 patients.
- Urinalyses were normal in all 99 patients.
- Five patients (0.4%) out of 1,130 registered Behçet's syndrome patients had systemic amyloidosis.
- All identified cases were of the AA type.
Conclusions:
- Systemic amyloidosis appears to be uncommon in Behçet's syndrome.
- Rectal biopsy may not be a sensitive method for detecting amyloidosis in Behçet's syndrome.
- AA-type amyloidosis is the predominant form in the few affected patients.