Related Experiment Video
Updated: May 26, 2026
09:39
Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish
Published on: December 26, 2014
[Acquired ichthyosis and haematological malignancies: five cases]
R Berrady1, H Baybay, Z Khammar
1Service de médecine interne, CHU Hassan II, Fès, Maroc. rhizberr@yahoo.fr
Annales De Dermatologie Et De Venereologie
|January 10, 2012
Summary
Acquired ichthyosis can indicate underlying blood cancers, appearing before other symptoms. Its regression or recurrence signals changes in the malignancy, aiding prognosis assessment.
Area of Science:
- Dermatology and Hematology
- Oncology
- Internal Medicine
Background:
- Acquired ichthyosis is a rare skin condition that can be an early indicator of hematological malignancies.
- Prompt diagnosis and management of underlying blood disorders are crucial.
Observation:
- A study examined five patients (3 men, 2 women; 38-65 years) presenting with acquired ichthyosis.
- Ichthyosis developed 2-9 months after initial symptoms like fatigue, anemia, or swollen lymph nodes.
- Skin lesions presented as diffuse brown scales, associated with lymphadenopathy and inflammatory markers.
Findings:
- The study identified various hematological malignancies, including non-Hodgkin lymphoma, Hodgkin's disease, chronic myeloid leukemia, and undifferentiated lymphoma.
- Ichthyosis progression mirrored the underlying malignancy in all patients.
- Complete or partial regression of ichthyosis was observed in three and one patient, respectively, while one showed no regression.
Implications:
- Acquired ichthyosis, often a paraneoplastic syndrome, necessitates a search for underlying neoplastic conditions, particularly hematological disorders.
- While not diagnostic, ichthyosis serves as a reliable monitoring tool for disease course and prognosis.
- Skin lesions may precede overt signs of blood disease, highlighting the importance of clinical vigilance.
Related Concept Videos
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
01:33Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...