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Updated: May 26, 2026
07:45
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
The high-risk myocardial infarction database initiative.
Kenneth Dickstein1, Judith Bebchuk, Janet Wittes
1University of Bergen, Bergen, Norway. kenneth.dickstein@med.uib.no
Progress in Cardiovascular Diseases
|January 10, 2012
Summary
This study merged data from four clinical trials to better understand high-risk patients after myocardial infarction (MI). The large dataset helps define prognostic profiles and event rates for cardiovascular disease management.
Area of Science:
- Cardiology
- Clinical Trials
- Epidemiology
Background:
- Coronary artery disease and myocardial infarction (MI) are leading causes of death.
- High-risk patients post-MI with heart failure or left ventricular dysfunction require precise prognostic understanding.
Purpose of the Study:
- To define the prognostic profile of high-risk post-MI patients.
- To conduct rigorous subset analyses and provide event rate estimations.
- To explore the utility of merged clinical trial data for scientific inquiry.
Main Methods:
- Merged data from four large randomized, controlled, double-blind clinical trials (VALIANT, EPHESUS, OPTIMAAL, CAPRICORN).
- Total of 28,771 high-risk patients following acute MI.
- Created a common database excluding randomized treatment for comparative analysis.
Main Results:
- Over 17,600 cardiovascular events and approximately 5100 deaths occurred.
- More than 15,700 hospitalizations were recorded.
- Demographic profiles across the four study cohorts were similar.
Conclusions:
- A merged database from large clinical trials offers valuable insights into high-risk populations.
- Methodological challenges in data merging and analysis were identified.
- Strategic planning can leverage accrued clinical events for future research questions.
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