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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
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Published on: August 25, 2021

Practical steps for establishing ocular plaque therapy in developing countries.

Imad Jaradat1, Layth Mula-Hussain, Shada Wadi-Ramahi

  • 1Brachytherapy Program, Department of Radiation Oncology, King Hussein Cancer Center, Amman, Jordan. ijaradat@khcc.jo

Brachytherapy
|January 10, 2012
PubMed
Summary
This summary is machine-generated.

Establishing plaque therapy, a vision-preserving ocular tumor treatment, is feasible in developing countries. Successful implementation requires a multidisciplinary team and integration with advanced cancer centers.

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Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Oncology

Background:

  • Retinoblastoma and uveal melanoma are common ocular tumors.
  • Current treatments like enucleation and external beam radiation therapy can be invasive.
  • Plaque therapy offers a globe-preserving alternative for ocular tumor management.

Purpose of the Study:

  • To report the successful implementation of plaque therapy at a center in a developing country.
  • To outline the practical steps and critical factors for establishing this complex brachytherapy technique.

Main Methods:

  • Review of institutional experience with plaque therapy implementation.
  • Emphasis on the role of a specialized multidisciplinary team.
  • Highlighting the importance of integration with an advanced cancer center.

Main Results:

  • Plaque therapy was successfully established within 1.5 years.
  • The integration with an advanced cancer center was crucial for technology transfer.
  • Demonstrated feasibility of complex brachytherapy in developing countries.

Conclusions:

  • Plaque therapy can be successfully established in developing countries.
  • A specialized multidisciplinary team is essential for successful implementation.
  • Integration with advanced cancer centers facilitates the transfer of complex brachytherapy technology.