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Related Experiment Video

Updated: May 26, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Skin telocytes.

M C Rusu¹, N Mirancea, V S Mănoiu

¹Discipline of Anatomy, Department MD, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. anatomon@gmail.com

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft

|January 10, 2012

Summary

This summary is machine-generated.

Telocytes (TCs), a unique stromal cell type, were identified in human skin dermis. These cells, characterized by long telopodes, interact with fibroblasts, mast cells, and adipocytes, suggesting a role in skin structure.

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Area of Science:

Cell Biology
Dermatology
Histology

Background:

Telocytes (TCs) are distinctive stromal cells known for their long prolongations called telopodes.
TCs have been identified in various stromal tissues, but their presence in skin remained unconfirmed.

Purpose of the Study:

To investigate the existence and characteristics of telocytes in human skin dermis.
To understand the relationship between skin telocytes and other dermal cells.

Main Methods:

Transmission electron microscopy (TEM) was employed to examine the ultrastructure of the human skin dermis.
Cellular morphology and intercellular connections were analyzed using high-resolution imaging.

Main Results:

Telocytes (TCs) with characteristic telopodes were identified in the human skin dermis.
Skin TCs were observed in close proximity to or in direct contact with fibroblasts, mast cells, adipocytes, and connective fibers (collagenous and elastic).

Conclusions:

This study provides the first evidence for the presence of telocytes in human skin.
Skin telocytes are integrated within the dermal microenvironment, interacting with other stromal cells and structural components, particularly elastic fibers, warranting further investigation.