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Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular cargos...

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Related Experiment Video

Updated: May 26, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

Cilia functions in development.

Iain A Drummond1

  • 1Nephrology Division, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, 149, 13th Street, Charlestown, MA 02129, United States. idrummond@partners.org

Current Opinion in Cell Biology
|January 10, 2012
PubMed
Summary
This summary is machine-generated.

Cilia are crucial for cell development and human diseases. Recent studies clarify their roles in cell fate, asymmetry, and signaling pathways like Hedgehog, impacting congenital disorders.

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Using Primary Neurosphere Cultures to Study Primary Cilia
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Related Experiment Videos

Last Updated: May 26, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Cilia play essential roles in developmental cell fate decisions and left-right asymmetry.
  • Cilia are implicated in the pathology of human congenital disorders.
  • Recent advances in genetics have elucidated gene functions related to cilia.

Purpose of the Study:

  • To review recent studies clarifying the role of cilia in development.
  • To highlight the importance of cilia in cell fate, asymmetry, and disease.

Main Methods:

  • Review of recent scientific literature.
  • Selection of key studies illustrating cilia function.
  • Analysis of genetic and developmental data.

Main Results:

  • Hedgehog signaling in sensory cilia involves receptor trafficking (Patched, Smoothened) and gatekeeper complexes (Suppressor of fused: Gli).
  • Motile cilia in the embryonic node generate and detect mechanical signals crucial for development.
  • Studies confirm cilia's fundamental role in various developmental processes.

Conclusions:

  • Cilia are vital for normal embryonic development and are implicated in congenital diseases.
  • Understanding cilia function is key to addressing developmental disorders.
  • Further research into cilia mechanisms will advance developmental biology and medicine.