Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injury-induced Cxcl11 and neutrophil signaling drive zebrafish kidney regeneration by generating a nephrogenic niche of Fgf and Wnt expression.

bioRxiv : the preprint server for biology·2026
Same author

Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney.

Development (Cambridge, England)·2026
Same author

Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same author

Effect of therapeutic plasma exchange on acquired hypocholesterolemia in patients with septic shock: a post hoc analysis of the two exchange trials.

Critical care (London, England)·2026
Same author

Unmasking EGPA with near fatal diffuse alveolar haemorrhage in severe eosinophilic asthma under treatment with benralizumab: a case report.

BMC pulmonary medicine·2026
Same author

Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction.

Kidney international·2025

Related Experiment Video

Updated: May 10, 2025

Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury
06:25

Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury

Published on: August 3, 2015

10.8K

Kidney development, injury and regeneration-Zebrafish.

Heiko Schenk1, Iain A Drummond2

  • 1Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; Mount Desert Island Biological Laboratory, Bar Harbor, ME, United States.

Current Topics in Developmental Biology
|April 20, 2025
PubMed
Summary

Zebrafish can regenerate kidney function after injury by forming new nephrons. Studying zebrafish kidney regeneration may lead to new human kidney repair therapies.

Keywords:
Acute kidney injuryChronic kidney diseaseKidney progenitor cellsRegenerationStem cellsZebrafish

More Related Videos

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

43.9K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

8.8K

Related Experiment Videos

Last Updated: May 10, 2025

Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury
06:25

Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury

Published on: August 3, 2015

10.8K
Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

43.9K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

8.8K

Area of Science:

  • Nephrology
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Acute kidney injury (AKI), acute kidney disease (AKD), and chronic kidney disease (CKD) affect millions globally, posing significant healthcare and economic challenges.
  • Current treatments for kidney diseases focus on slowing progression, often leading to end-stage kidney disease (ESKD) requiring dialysis or transplantation.
  • Limited organ availability for transplantation necessitates the development of novel regenerative therapies for kidney repair.

Purpose of the Study:

  • To explore the potential of zebrafish as a model organism for studying kidney development and regeneration.
  • To investigate the mechanisms underlying kidney regeneration in zebrafish following injury.
  • To identify key pathways and progenitor cells involved in renal repair for translational applications in humans.

Main Methods:

  • Utilizing zebrafish to model acute kidney injury (AKI) and observe regeneration processes.
  • Investigating the capacity of zebrafish to form new nephrons that integrate into the existing renal tubular network.
  • Analyzing the role of kidney progenitor cells in adult zebrafish for injury-induced regeneration.

Main Results:

  • Zebrafish demonstrate remarkable kidney regeneration capabilities after AKI.
  • New nephrons are formed and successfully integrated into the renal system post-injury.
  • Adult zebrafish possess a distinct niche of kidney progenitor cells crucial for regenerative processes.

Conclusions:

  • Zebrafish serve as a powerful model for understanding kidney development and injury-induced regeneration.
  • The study of zebrafish regeneration pathways offers insights into potential human kidney regenerative therapies.
  • Identifying key regenerative mechanisms in zebrafish could pave the way for novel treatments for kidney diseases.