Related Experiment Video
Updated: May 26, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
Evaluation of the screening power of Cognitive Abilities Screening Instrument for probable Alzheimer's disease using
Greta S P Mok1, Yi-Ying Wu, Kun-Mu Lu
1Department of Electrical and Electronics Engineering, Faculty of Science and Technology, University of Macau, Macau.
Objective:
The aim of this study was to compare two screening methods, total score of the Cognitive Abilities Screening Instrument (CASI(T)) and the combined score for the short-term memory and orientation domains (CASI(R)) for screening and grading probable Alzheimer's disease (AD), based on their correlations with voxel-based morphometry (VBM).
Materials And Methods:
Forty-five subjects with probable AD and normal controls underwent magnetic resonance imaging and CASI testing. Their corresponding T1-weighted magnetic resonance images were analyzed using VBM.
Results:
VBM results showed that in moderate-to-severe AD subgroups, significant whole-brain gray matter loss was detected using both CASI(T) and CASI(R). Significantly more voxels were detected using the CASI(T) compared with the CASI(R) system in mild AD subjects (P<.05).
Conclusions:
Based on their correlations with VBM results, there is no significant difference for CASI(R) and CASI(T) for grading moderate-to-severe AD subgroups, and CASI(R) scoring system may be more accurate and effective than the CASI(T) for screening mild AD.
More Related Videos
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
12:50Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Published on: April 14, 2014
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Alzheimer's Disease: Treatment
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction