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Analysis of aging in Caenorhabditis elegans
Deepti S Wilkinson1, Rebecca C Taylor, Andrew Dillin
1Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Methods in Cell Biology
|January 10, 2012
Summary
This chapter details aging assays in Caenorhabditis elegans (C. elegans), covering lifespan analysis and age-related changes. It provides protocols to aid researchers studying C. elegans aging.
Area of Science:
- Gerontology
- Developmental Biology
- Genetics
Background:
- Aging research is complex and requires specialized techniques.
- Caenorhabditis elegans (C. elegans) is a powerful model organism for studying aging.
- Access to C. elegans expertise and protocols can be a barrier for non-specialist researchers.
Purpose of the Study:
- To provide a comprehensive guide for aging assays in C. elegans.
- To detail protocols for lifespan analysis in both solid and liquid media.
- To describe various assays for measuring age-related physiological changes.
Main Methods:
- Lifespan analysis protocols for C. elegans in solid and liquid environments.
- Detailed descriptions of assays to quantify age-related changes.
- Guidance for researchers collaborating on C. elegans aging studies.
Main Results:
- Established protocols for C. elegans lifespan determination.
- A compendium of assays for assessing age-related changes in C. elegans.
- Facilitation of interdisciplinary research in aging.
Conclusions:
- This chapter serves as a valuable resource for C. elegans aging research.
- The provided protocols aim to make aging assays more accessible.
- It supports researchers in exploring genetic factors influencing aging in C. elegans.
