Related Experiment Video

Updated: May 26, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Recent progress in targeting cancer

Zoya N Demidenko1, James A McCubrey

  • 1Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. zoya.demidenko@roswellpark.org

Aging
|January 10, 2012
PubMed

Insights

Recent cancer research highlights novel therapeutic strategies and repurposed non-cancer drugs for improved treatment efficacy. Advances focus on increasing drug potency and selectivity while minimizing adverse effects in cancer therapy.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Numerous novel cancer targets have been identified recently.
  • New experimental therapeutics are continuously being developed.
  • Existing non-cancer drugs are finding new applications in cancer treatment.

Purpose of the Study:

  • To review recent advances in cancer targeting strategies.
  • To highlight the development of novel therapeutics.
  • To discuss the repurposing of non-cancer drugs for oncology.

Main Methods:

  • Literature review of recent advancements in cancer therapy.
  • Analysis of experimental therapeutics and novel drug targets.
  • Evaluation of strategies to enhance drug potency and selectivity.

Main Results:

  • Identification of numerous new therapeutic targets in cancer.
  • Successful repurposing of existing non-cancer drugs for cancer treatment.
  • Development of strategies to improve therapeutic efficacy and reduce side effects.

Conclusions:

  • Significant progress has been made in developing novel cancer therapies.
  • Drug repurposing offers a promising avenue for cancer treatment.
  • Ongoing research focuses on enhancing treatment selectivity and minimizing toxicity.

More Related Videos

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...