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Updated: May 26, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Th17 response and inflammatory autoimmune diseases.

Janelle C Waite¹, Dimitris Skokos

¹Department of Immunity and Inflammation, Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

International Journal of Inflammation

|January 10, 2012

Summary

T helper 17 (Th17) cells, crucial for fighting infection, can also drive autoimmune diseases. Their potential role in adult-onset Still

Area of Science:

Immunology
Autoimmunity
Cell Biology

Background:

T helper 17 (Th17) cells possess proinflammatory functions beneficial during infections.
Dysregulated Th17 activation is implicated in various autoimmune and autoinflammatory diseases.
Th17 cells are associated with conditions like arthritis, multiple sclerosis, psoriasis, and lupus.

Purpose of the Study:

To discuss the fundamental biology of Th17 cells.
To review the established role of Th17 cells in autoimmune disease pathogenesis.
To explore the emerging evidence and potential involvement of Th17 cells in adult-onset Still's disease (AOSD).

Main Methods:

Literature review of preclinical and clinical data on Th17 cells in autoimmunity.
Analysis of existing research on the interleukin-17 (IL-17) pathway.

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Discussion of recent findings linking Th17 cells to adult-onset Still's disease (AOSD).

Main Results:

Targeting the IL-17 pathway has shown therapeutic potential in autoimmune disease models.
A recent report suggests a possible role for Th17 cells in adult-onset Still's disease (AOSD).
The precise causal or direct involvement of Th17 cells in AOSD requires further investigation.

Conclusions:

Th17 cells are key players in both host defense and autoimmune pathologies.
The therapeutic targeting of Th17 cells and the IL-17 pathway is a growing area of pharmaceutical interest.
Further research is needed to elucidate the specific role of Th17 cells in adult-onset Still's disease (AOSD).