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Published on: March 23, 2016
New oral solid dosage form for furosemide oral administration
Luana Perioli1, Giuseppina D'Alba, Cinzia Pagano
1Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Perugia, Italy. luanaper@unipg.it
Summary
This study improved furosemide (FURO) oral drug delivery by creating a composite with hydrotalcite. The new formulation significantly enhanced furosemide dissolution and release, offering a promising solid oral dosage form.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Furosemide (FURO) exhibits poor solubility and permeability, classifying it as a Biopharmaceutics Classification System (BCS) Class IV drug.
- Improving the biopharmaceutical properties of FURO is crucial for effective oral drug delivery.
Purpose of the Study:
- To enhance the biopharmaceutical properties of furosemide (FURO) through formulation into a novel solid oral dosage form.
- To develop a composite material (MgAl-HTlc-FURO) by intercalating FURO into hydrotalcite (MgAl-HTlc) and formulate it into rapidly disintegrating tablets.
Main Methods:
- Preparation of MgAl-HTlc-FURO composite via intercalation of FURO into MgAl-HTlc.
- Formulation of tablets by direct compression using the composite, super disintegrants, and fillers.
- Evaluation of tablet disintegration time in a gastric medium.
- In vitro drug release studies comparing MgAl-HTlc-FURO tablets with controls (crystalline FURO alone or physically mixed).
Main Results:
- Tablets containing the MgAl-HTlc-FURO composite demonstrated superior dissolution profiles compared to controls.
- L-HPCLH-21 was identified as the most effective super disintegrant, promoting the highest drug release in the gastric medium.
- Rapid disintegration and enhanced drug release were achieved with the optimized formulation.
Conclusions:
- The MgAl-HTlc-FURO composite formulation significantly improves the dissolution and release characteristics of furosemide.
- Rapidly disintegrating tablets incorporating MgAl-HTlc-FURO, particularly with L-HPCLH-21, represent a promising approach for enhancing oral delivery of poorly soluble and permeable drugs like FURO.
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