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Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Microbial Interactions: Parasitism01:22

Microbial Interactions: Parasitism

Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
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Microbe-Plant Interactions

Microbe-plant interactions represent a dynamic spectrum of associations shaped by intricate chemical signaling. These interactions can be neutral, beneficial, or detrimental, and profoundly influence plant physiology, growth, and ecosystem function. The plant microbiome, comprising bacteria, fungi, archaea, protists, and viruses, plays a pivotal role in mediating these effects through surface colonization, internal colonization, or systemic symbiosis.Mutualistic associations, particularly with...
Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
Microbial Interactions: Cooperation01:26

Microbial Interactions: Cooperation

Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions
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Polymicrobial interactions: impact on pathogenesis and human disease.

Brian M Peters1, Mary Ann Jabra-Rizk, Graeme A O'May

  • 1Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland—Baltimore, Baltimore, Maryland, USA.

Clinical Microbiology Reviews
|January 11, 2012
PubMed
Summary
This summary is machine-generated.

Human body microorganisms form complex polymicrobial biofilms. This review explores microbial interactions in these biofilms during infection and discusses protection strategies against polymicrobial diseases.

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Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
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Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

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Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biofilm Formation

Background:

  • Microorganisms like bacteria, fungi, archaea, and viruses form complex communities.
  • These microbes often exist as polymicrobial biofilms on human surfaces.
  • The role of microbial interactions within biofilms during infection is not well understood.

Purpose of the Study:

  • To review polymicrobial biofilm-mediated infections.
  • To examine interactions between different microorganisms within biofilms.
  • To discuss potential strategies for protection against these infections.

Main Methods:

  • Literature review of polymicrobial biofilm research.
  • Analysis of bacterial-bacterial, bacterial-fungal, and bacterial-viral interactions.
  • Exploration of implications for human disease and therapeutic strategies.

Main Results:

  • Polymicrobial biofilms are significant in human infections.
  • Interactions between different microbial species influence disease pathogenesis.
  • Understanding these interactions is crucial for developing effective treatments.

Conclusions:

  • Polymicrobial biofilms present a complex challenge in infectious diseases.
  • Targeting inter-microbial interactions within biofilms may offer novel therapeutic approaches.
  • Further research into these interactions is needed to combat polymicrobial infections effectively.