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Updated: May 26, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Synovial sarcoma of the thyroid gland
Chang Hwan Ryu1, Kyung-Ja Cho, Seung-Ho Choi
1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Clinical and Experimental Otorhinolaryngology
|January 11, 2012
Summary
Primary synovial sarcoma of the thyroid is exceptionally rare. This case highlights its aggressive nature, rapid progression, and the need for early diagnosis and comprehensive treatment for this rare thyroid cancer.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Primary synovial sarcoma of the thyroid is an exceedingly rare malignancy.
- Fewer than three cases have been documented in medical literature.
- This report details a unique and aggressive presentation.
Purpose of the Study:
- To report an extremely rare case of primary synovial sarcoma of the thyroid.
- To describe the clinical, histological, and genetic features of this aggressive tumor.
- To emphasize the importance of early diagnosis and multimodal treatment.
Main Methods:
- Case presentation of a 72-year-old female with thyroid mass.
- Histopathological and immunohistochemical analysis of the tumor.
- Molecular detection of the SYT/SSX fusion transcript for diagnosis.
Main Results:
- The patient presented with extensive local invasion, rapid tumor progression, and early distant metastasis.
- Histology revealed an atypical pattern, confirmed by immunohistochemistry.
- The SYT/SSX fusion transcript positively identified the tumor as synovial sarcoma.
Conclusions:
- Primary thyroid synovial sarcoma is highly aggressive and often lethal.
- Early diagnosis is critical for effective management.
- Comprehensive treatment, including surgery and adjuvant chemoradiation, is essential.
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