[Influence high-fat ration on plasma and erythrocyte lipids fatty acids of rats]

Study character of the redistribution of fatty acids between the lipid fraction of plasma and erythrocytes in rats with prolonged high-fat diet (30, 90, 180 days). Shown that at long high-fat rations in the lipids of erythrocytes decreasing pool polyunsaturated fatty acids (oleic, dihomo-gamma-linoleic, eicosapentaenoic, arachidonic), increases of saturated fatty acids (myristic, stearic) levels. In lipids fractions of plasma revealed the opposite direction of changes in the level of the fatty acids: the accumulation of essential polyunsaturated fatty acids, reduction of saturated fatty acids. Supposedly, that high-fat diet promotes de novo compensatory synthesis of polyunsaturated fatty acids, but disturbed apoB-100 receptor-mediated active transport of fatty acids with low-density lipoproteins (LDL), synthesized in the liver fatty acids is not captured by the cells peripheral organs. Marker of the apoB-100 receptor breach of transfer low-density lipoprotein, transporting polyunsaturated fatty acids was to increase LDL cholesterol in serum.