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Related Concept Videos

Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...

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Related Experiment Video

Updated: May 26, 2026

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

[Nuclear texture in mitotic cells].

L I Lebedeva, T D Dubatolova, L V Omel'ianchuk

    Tsitologiia
    |January 12, 2012
    PubMed
    Summary

    This study quantifies nuclear texture changes during Drosophila mitosis using DAPI fluorescence. These specific texture alterations enable more precise staging of cell division and analysis of mitotic pathologies.

    Area of Science:

    • Cell Biology
    • Developmental Biology
    • Genetics

    Context:

    • Investigating cell division dynamics in Drosophila melanogaster imaginal discs.
    • Utilizing DAPI fluorescence intensity distribution as a quantitative measure of nuclear texture.
    • Analyzing integral characteristics like voxel distribution and pixel intensity autocorrelation.

    Purpose:

    • To characterize specific changes in nuclear texture during different stages of mitosis.
    • To establish nuclear texture analysis as a method for precise mitotic staging.
    • To explore the application of the nuclear-texture approach in studying pathologies associated with abnormal mitoses, such as those induced by colchicine treatment.

    Summary:

    • Nuclear texture, quantified by DAPI fluorescence intensity distribution and autocorrelation, exhibits distinct changes throughout mitosis in Drosophila imaginal disc cells.

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    Anti-Nuclear Antibody Screening Using HEp-2 Cells
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    Anti-Nuclear Antibody Screening Using HEp-2 Cells

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    Last Updated: May 26, 2026

    Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
    12:04

    Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

    Published on: June 24, 2019

    Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
    07:14

    Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

    Published on: September 20, 2019

    Anti-Nuclear Antibody Screening Using HEp-2 Cells
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    Anti-Nuclear Antibody Screening Using HEp-2 Cells

    Published on: June 23, 2014

  • These dynamic nuclear texture alterations correlate with specific mitotic stages, offering a novel approach for precise cell cycle staging.
  • The study demonstrates the potential of this nuclear-texture approach to identify and analyze mitotic abnormalities induced by agents like colchicine.

    • Impact:

    • Provides a novel, quantitative method for precise staging of mitosis in Drosophila.
    • Offers new insights into the dynamic changes of nuclear architecture during cell division.
    • Establishes a foundation for using nuclear texture analysis to study the mechanisms of mitotic errors and drug-induced pathologies.