Related Experiment Video
Updated: May 26, 2026

In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors
Published on: July 19, 2014
[Provisionality phenomenon in the histo- organo- and systemogenesis]
This study reveals provisionality stages in organ development across vertebrates, highlighting a saltatory mechanism in embryonic development and oncogenesis. These findings offer insights into tissue transformation and regeneration.
Area of Science:
- Developmental Biology
- Regenerative Medicine
- Oncology
Context:
- Reviews the provisionality phenomenon in organogenesis across diverse amniotes (viviparous and oviparous).
- Examines reparative regeneration in human and hamster tissues.
- Investigates hepatic cancer morphogenesis linked to opisthorchiasis.
Purpose:
- To elucidate the stages of provisional and definitive histo- and organogenesis.
- To identify the saltatory mechanism in embryonic development and oncogenesis.
- To understand epithelial transformation zones and their underlying mechanisms.
Summary:
- Provisionality stages are identifiable in organ development, including urinary systems (mesonephros, metanephros) and mixed-origin organs (pituitary, ovary, stomodeum).
- A saltatory mechanism characterizes embryonic organogenesis and oncogenesis, observed in skeletal primordia and nephrons.
- Epithelial transformation zones, particularly in the stomodeum and Rathke's pouch, involve local apoptosis and new cell generation.
Impact:
- Provides a framework for understanding tissue and organ development and regeneration.
- Offers insights into the mechanisms driving oncogenesis.
- Enhances knowledge of epithelial plasticity and developmental processes.
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