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Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers
Erika L Smith1, Adrienne S Brown, Edward Adjaye-Mensah
1Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33124, USA.
Organic & Biomolecular Chemistry
|January 12, 2012
Abstract:
A series of stilbazolium dimers were synthesized and investigated as sterically demanding ligands targeting the norepinephrine transporter (NET). The environmentally sensitive fluorescence of the dyes enables their use as self-reporting ligands; binding to and displacement from NET can be monitored by fluorescence microscopy.
