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Updated: May 25, 2026

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
Published on: August 30, 2024
Intramolecular folding in three tandem guanine repeats of human telomeric DNA
Deepak Koirala1, Tomoko Mashimo, Yuta Sannohe
1Department of Chemistry & Biochemistry, Kent State University, Kent, OH 44242, USA.
Abstract:
Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem guanine repeats.
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