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Structure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and

Nigel J Otto1, Dixy E Green, Sayaka Masuko

  • 1Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA.

The Journal of Biological Chemistry
|January 12, 2012
PubMed
Summary

Pasteurella multocida heparosan synthases (PmHS1 and PmHS2) create the glycosaminoglycan heparosan. Chimeric enzymes revealed structure-function relationships, identifying regions for donor binding and acceptor usage.

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