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Granulosa cell tumors of the ovary and inhibin B

N V Lyubimova1, A M Beyshembaev, D N Kushlinskiy

  • 1N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. biochimia@mtu-net.ru

Bulletin of Experimental Biology and Medicine
|January 12, 2012
PubMed

We present the results of immunoenzyme detection of inhibin B in blood serum of patients with adult-type granulosa cell tumors of the ovary. Blood concentration of inhibin B at the end of menstrual cycle in patients with tumor relapse was significantly higher than in patients during remission and in virtually healthy women. The increase in inhibin B concentration preceded clinical manifestation of the disease relapse by 2-13 months, which demonstrates high diagnostic sensitivity of this marker and suggests that it can be recommended for the use in diagnostics and monitoring of granulosa cell tumors of the ovaries.

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