Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of prepartum exercise on lying behavior, labor length, and cortisol concentrations.

Journal of dairy science·2019
Same author

Development of a Bioactive Polymeric Drug Eluting Coronary Stent Coating Using Electrospraying.

Annals of biomedical engineering·2019
Same author

Effect of prepartum exercise, pasture turnout, or total confinement on hoof health.

Journal of dairy science·2017
Same author

Effect of maternal exercise on calf dry matter intake, weight gain, behavior, and cortisol concentrations at disbudding and weaning.

Journal of dairy science·2017
Same author

Effects of bedding with recycled sand on lying behaviors, udder hygiene, and preference of lactating Holstein dairy cows.

Journal of dairy science·2017
Same author

Aseasonal leaf abscission in Populus induced by volcanic ash.

Oecologia·2017

Related Experiment Video

Updated: May 25, 2026

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Modelling the lymphatic system: challenges and opportunities.

K N Margaris1, R A Black

  • 1Department of Bioengineering, University of Strathclyde, 106 Rottenrow, Glasgow G4 0NW, UK. konstantinos.margaris@strath.ac.uk

Journal of the Royal Society, Interface
|January 13, 2012
PubMed
Summary
This summary is machine-generated.

Mathematical modeling of the lymphatic system, crucial for immunity and fluid balance, lags behind cardiovascular research. Further research and experimental validation are needed to advance understanding and develop treatments for lymphatic diseases.

Related Experiment Videos

Last Updated: May 25, 2026

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Area of Science:

  • Biological Systems Modeling
  • Lymphatic System Physiology
  • Immunology

Background:

  • The lymphatic system is integral to circulatory and immune functions, maintaining fluid balance and fighting infection.
  • Research on lymphatic diseases is significantly less extensive than for cardiovascular diseases, despite anatomical and physiological similarities and differences.
  • The mathematical modeling of the lymphatic system is a relatively new field, with most models developed since 2003.

Purpose of the Study:

  • To review the challenges and opportunities in biological systems modeling of the lymphatic system.
  • To highlight the current limitations in lymphatic system research and mathematical modeling.
  • To emphasize the need for increased research and experimental validation to advance understanding and treatment of lymphatic diseases.

Main Methods:

  • Literature review of existing mathematical models for the lymphatic system.
  • Analysis of the current state of research in lymphatic system biology and disease.
  • Identification of gaps in current modeling approaches, particularly concerning lymphatic nodes.

Main Results:

  • The study of the lymphatic system, especially through mathematical modeling, is still in its early stages.
  • There is a limited number of distinct mathematical models for the lymphatic system, with few attempts to model the entire network.
  • Key lymphatic components like lymph nodes have not been adequately addressed by mathematical models.

Conclusions:

  • Significant advancements in understanding lymphatic system function require more extensive research and experimental verification.
  • Developing comprehensive mathematical models is crucial for progressing lymphatic system research.
  • Increased knowledge is expected to lead to the development of novel and more effective treatments for lymphatic diseases.