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Development of a Bioactive Polymeric Drug Eluting Coronary Stent Coating Using Electrospraying

C M McKittrick1, M J Cardona2, R A Black2

  • 1Department of Biomedical Engineering, University of Strathclyde, Graham Hills Building, 40 George Street, Glasgow, G1 1QE, UK. craig.m.mckittrick@strath.ac.uk.

Annals of Biomedical Engineering
|August 24, 2019
PubMed

Insights

Researchers developed a novel drug-eluting stent coating using electrospray deposition. This new coating promotes endothelial regrowth and controlled drug release, potentially improving treatment for coronary artery disease patients.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Medicine
  • Drug Delivery Systems

Background:

  • Drug-eluting stents (DES) reduce repeat revascularization for coronary artery disease but delay endothelial regrowth, necessitating prolonged dual anti-platelet therapy.
  • Current DES technologies have limitations, failing to fully address issues like delayed re-endothelialization and associated risks.
  • There is a need for advanced stent coatings that balance anti-proliferative drug delivery with promotion of vascular healing.

Purpose of the Study:

  • To develop a novel stent coating with controlled sirolimus release from a bioactive polymer.
  • To utilize electrospray deposition for precise control over coating characteristics and drug release kinetics.
  • To create a dual-action coating promoting re-endothelialization and preventing in-stent restenosis and thrombosis.

Main Methods:

  • Development of a novel stent coating using a bioactive polymer (accelerate™ AT) and sirolimus.
  • Application of a bespoke electrospray deposition technique to control coating thickness, surface roughness, drug load, and release profile.
  • In vitro evaluation of the coating's ability to support endothelial cell growth and controlled drug release.

Main Results:

  • The electrospray deposition process allowed precise control over coating parameters.
  • The optimized coating demonstrated rapid release of an anti-proliferative agent.
  • The bioactive polymer component of the coating was shown to support endothelial cell growth in vitro.

Conclusions:

  • A novel dual-action stent coating was successfully developed, combining controlled drug release with enhanced re-endothelialization.
  • The electrospray deposition method offers precise control, enabling potential for personalized treatment approaches.
  • This innovative coating shows significant therapeutic potential for reducing in-stent restenosis and thrombosis in cardiovascular disease.

Keywords:
Drug releaseDrug-eluting stentElectrohydrodynamic sprayingIn-stent restenosisStent-thrombosis

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