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Updated: Dec 27, 2025

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

Protein databases on the Internet.

¹Department of Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.

Current Protocols in Molecular Biology

|January 13, 2012

Summary

This summary is machine-generated.

Protein databases are vital for modern biology, offering extensive data on protein sequences, structures, and functions. Exploring these resources aids in understanding protein relationships and functions, even for novel proteins.

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Last Updated: Dec 27, 2025

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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Area of Science:

Molecular Biology
Bioinformatics
Genomics

Background:

The generation of vast amounts of data on protein sequences, structures, and functions is a hallmark of modern biology.
Protein databases serve as a primary resource for initial investigations into newly discovered proteins.

Purpose of the Study:

To highlight the critical role and underutilization of protein databases in the scientific community.
To provide a foundational guide for researchers to explore and leverage internet-based protein databases.

Main Methods:

Database searching for protein sequence, structure, and function analysis.
Comparative analysis of proteins and protein families across species and genomes.
Utilizing secondary databases for data reorganization, annotation, and prediction.

Main Results:

Database searches are fundamental for studying new proteins.
Cross-species and cross-genome protein comparisons reveal evolutionary and functional relationships.
Integrated use of multiple databases enhances understanding of protein structure and function.

Conclusions:

Protein databases are indispensable tools in biological research.
Effective utilization of existing protein databases can significantly advance protein science.
This guide serves as an entry point to harness the full potential of online protein databases.