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Updated: May 25, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
Published on: May 18, 2018
Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells
Arthur A Hurwitz1, Stephanie K Watkins2
1Tumor Immunity and Tolerance Section, Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, National Cancer Institute, 211 Building 567, 1050 Boyles Street, NCI-Frederick, Frederick, MD, 21702, USA. hurwitza@mail.nih.gov.
Abstract:
Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.
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