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Updated: May 25, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Planar-bilayer activities of linear oligoester bolaamphiphiles
Jonathan K W Chui1, Thomas M Fyles, Horace Luong
1Department of Chemistry, University of Victoria, Victoria BC, Canada.
Abstract:
Voltage-clamp experiments of eight oligoester bolaamphiphiles in two subclasses are described. Syntheses of three new terephthalate-based compounds were achieved in three linear steps. Together with five previously described, related compounds, the ion transport activity was assessed by means of the voltage-clamp technique. All of the compounds show multiple types of conductance behavior in planar bilayers, a subset of which was exponentially voltage-dependent. The varied and irregular activities were summarized with the aid of a recently developed "activity-grid" method.
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