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Updated: May 25, 2026
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Published on: June 14, 2016
Using extracellular matrix-derived peptides to alter the microenvironment for myocardial repair
Shirley S Mihardja1, Randall J Lee
1University of California San Francisco, Francisco, CA 94143, USA.
Abstract:
Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.
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