Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 25, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Tissue engineering a small diameter vessel substitute: engineering constructs with select biomaterials and cells.

Joanne E McBane1, Soroor Sharifpoor, Rosalind S Labow

  • 1University of Toronto, Toronto, ON, Canada.

Current Vascular Pharmacology
|January 14, 2012
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noninvasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Localized Tacrolimus Delivery for Peripheral Nerve Regeneration: Molecular Mechanisms, Biomaterial Platforms, and Translational Strategies.

International journal of molecular sciences·2026
Same author

Advances in stem cell-based tissue-engineered skin substitutes for burns.

Trends in biotechnology·2026
Same author

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

The effect of perfusion with and without mechanical loading on an in vitro model of the outer annulus fibrosus-cartilage endplate interface.

Acta biomaterialia·2026
Same author

Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components.

Nature communications·2026

Tissue engineering seeks viable small-caliber vascular grafts for cardiovascular disease (CVD). Current research focuses on biomaterials that recruit and sustain stem cells for effective blood vessel repair and regeneration.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Surgery

Background:

  • Cardiovascular disease (CVD) presents a significant global health challenge, driving demand for small-caliber vascular grafts (< 6mm).
  • Limited availability of autologous vessels necessitates the development of alternative graft sources.
  • Existing decellularized extracellular matrices (ECM) and synthetic scaffolds have not yet yielded a commercially viable solution.

Purpose of the Study:

  • This review focuses on the challenges in tissue-engineering small-caliber vascular grafts.
  • It highlights the critical need for biomaterial constructs that promote cell recruitment and functional maintenance.
  • The review emphasizes the shift towards understanding interactions with stem cells, progenitor cells, and monocytes for enhanced graft performance.

More Related Videos

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Related Experiment Videos

Last Updated: May 25, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Main Methods:

  • Review of existing literature on vascular graft biomaterials.
  • Analysis of cell-matrix interactions, focusing on fibroblasts, smooth muscle cells, endothelial cells, stem cells, progenitor cells, and monocytes.
  • Evaluation of material chemistry and biological functions essential for graft success.

Main Results:

  • Decades of research have yet to produce a commercially viable small-caliber vascular graft substitute.
  • Current research trends indicate that interactions with stem cells, progenitor cells, and monocytes are crucial for graft repair and regeneration.
  • The ability of a graft to recruit and sustain these specific cell types is a key area of investigation.

Conclusions:

  • Developing successful small-caliber vascular grafts requires optimizing material chemistry and biological functions.
  • Effective cell recruitment and maintenance of cell phenotype during vessel maturation are paramount.
  • Addressing these challenges is essential for advancing the field of vascular tissue engineering.