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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
Published on: October 25, 2024
Development and function of interleukin 17-producing γδ T cells
Thomas Korn1, Franziska Petermann
1Klinikum rechts der Isar, Department of Neurology, Technical University Munich, Ismaninger, Munich, Germany. korn@lrz.tum.de
Annals of the New York Academy of Sciences
|January 14, 2012
Summary
Interleukin 17 (IL-17) is produced by innate immune cells, particularly γδ T cells, at organism interfaces. This review explores γδ T cell commitment to IL-17 production and their role in autoimmunity and human diseases.
Area of Science:
- Immunology
- Cellular Biology
Background:
- Interleukin 17 (IL-17) is a critical cytokine with roles in adaptive immunity.
- Innate immune cells, especially γδ T cells, are significant producers of IL-17 at environmental interfaces like epithelial surfaces.
Purpose of the Study:
- To review the commitment of γδ T cells to effector phenotypes, specifically focusing on IL-17-producing γδ T cells (γδT17 cells).
- To discuss the role of γδT17 cells in animal models of autoimmunity.
- To explore the development and potential importance of human γδT17 cells in disease.
Main Methods:
- Literature review focusing on γδ T cell differentiation and function.
- Analysis of existing data on γδT17 cells in autoimmunity models.
- Examination of human γδT17 cell development and disease relevance.
Main Results:
- γδ T cells are a prominent source of IL-17, particularly at epithelial barriers.
- γδT17 cells play a role in the pathogenesis of autoimmune diseases in animal models.
- Prerequisites for human γδT17 cell development and their disease associations are being elucidated.
Conclusions:
- γδT17 cells are key innate immune players at organism interfaces, contributing to immunity and disease.
- Understanding γδT17 cell biology is crucial for developing new therapeutic strategies for autoimmune and inflammatory conditions.
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