Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fibronectins Connect Cells with ECM

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...

Mechanism of Filopodia Formation

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...

Cell-matrix's Response to Mechanical Forces

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...

Formation of Higher-order Actin Filaments

Formation of Higher-order Actin Filaments

The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin networks...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emergent cytotoxicity and mitochondrial alterations induced by a heterobimetallic Re(I)/Au(I) complex.

Chemical communications (Cambridge, England)·2026

Same author

High-throughput screening of FRET-based proteins using a hyperspectral microcapillary array.

iScience·2026

Same author

Relevance of the Hydrolysis State of Silyl Acrylate-Based Coatings on Their Antifouling Performance.

ACS applied materials & interfaces·2026

Same author

Magnetic and pneumatic actuation of polymeric microneedles for plasmonic hot-spot engineering and molecular sensing.

Nature communications·2025

Same author

Investigating Metal and Fluorophore Controlled Intracellular Localization in Noble Metal Thiosemicarbazone Complexes.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025

Same author

Impact of biomanufacturing protein fibers on achieving sustainable development.

Proceedings of the National Academy of Sciences of the United States of America·2025

Search research articles

Related Experiment Video

Updated: May 25, 2026

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Fibroblast adhesion on unidirectional polymeric nanofilms.

Christof Christophis¹, Koray Sekeroglu, Gokhan Demirel

¹Applied Physical Chemistry, University of Heidelberg, Germany.

|January 14, 2012

Summary

Fibroblast cells interact differently with nanotextured surfaces based on rod inclination. Cell removal force depends on direction, due to cellular filopodia interacting with the nanotexture.

More Related Videos

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

Related Experiment Videos

Last Updated: May 25, 2026

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

Area of Science:

Materials Science
Cell Biology
Surface Science

Background:

Nanotextured polymeric surfaces exhibit anisotropic properties.
Understanding cell interactions with these materials is crucial for biomedical applications.

Purpose of the Study:

Investigate fibroblast cell interaction with nanotextured surfaces featuring inclined rods.
Quantify the anisotropic adhesion and removal of cells.

Main Methods:

Utilized nanotextured polymeric surfaces with inclined rods.
Applied laminar flow to quantify cell removal.
Analyzed cell-surface interactions using electron microscopy.

Main Results:

Cell removal force from the nanotextured surface is direction-dependent.
Critical shear force varies with the inclination direction of the surface rods.
Electron microscopy revealed interactions between cellular filopodia and the nanotexture.

Conclusions:

Cellular filopodia extending into the nanotextured surface cause direction-dependent cell removal.
The anisotropic nature of the nanotexture significantly influences cell adhesion and removal dynamics.