Related Experiment Video
Updated: May 25, 2026
10:46
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Retrobulbar hemodynamic parameters in open-angle and angle-closure glaucoma patients
I Marjanovic1, N Milic, A Martinez
1Glaucoma Department, University Eye Clinic, Clinical Centre of Serbia, Belgrade, Serbia.
Eye (London, England)
|January 14, 2012
Summary
Open-angle glaucoma (OAG) patients exhibit increased resistance in the ophthalmic artery compared to angle-closure glaucoma (ACG) patients. This circulatory disturbance is not linked to intraocular pressure or visual-field damage.
Area of Science:
- Ophthalmology
- Vascular Physiology
- Glaucoma Research
Background:
- Glaucoma encompasses various subtypes, including open-angle glaucoma (OAG) and angle-closure glaucoma (ACG).
- Retrobulbar hemodynamics play a crucial role in ocular health and disease progression.
- Understanding hemodynamic differences between glaucoma types is vital for diagnosis and management.
Purpose of the Study:
- To compare retrobulbar hemodynamic parameters in the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCA).
- To investigate these parameters in patients with open-angle glaucoma (OAG) versus angle-closure glaucoma (ACG).
Main Methods:
- A cross-sectional study included 52 eyes with OAG and 25 eyes with ACG.
- Assessed peak-systolic velocity, end-diastolic velocity, and Pourcelot resistivity index (RI) in OA, CRA, and PCA.
- Measured intraocular pressure (IOP) using Goldmann applanation tonometer (GAT) and Dynamic Contour tonometer (DCT), and ocular pulse amplitude via DCT.
Main Results:
- The RI was significantly higher in the OA and short PCA of OAG patients compared to ACG patients (P=0.003 and 0.048, respectively).
- No correlation was found between IOP (measured by GAT) and retrobulbar hemodynamic parameters in either OAG or ACG groups.
Conclusions:
- OAG patients demonstrate increased blood flow resistance in the OA compared to ACG patients.
- The extent of circulatory disturbance in glaucoma is independent of IOP or visual-field damage.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...