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Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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[Research for cell therapy by induced pluripotent stem cell].

Hidetoshi Sakurai¹, Shinya Yamanaka

¹Center for iPS Cell Research and Application (CiRA), Kyoto University.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|January 17, 2012

Summary

Induced pluripotent stem (iPS) cells offer promise for treating diseases. This review covers iPS cell therapies and strategies to mitigate tumorigenesis risks for clinical use.

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Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

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Area of Science:

Stem cell biology
Regenerative medicine
Biotechnology

Context:

Induced pluripotent stem (iPS) cells are derived from somatic cells, offering potential for regenerative medicine.
Their unlimited proliferation and differentiation capabilities make them suitable for autotransplantation.
Significant research is exploring the clinical applications of iPS cell technology.

Purpose:

To review the advancements in iPS cell research for therapeutic applications.
To highlight new iPS cell technologies and their potential.
To address the major hurdle of tumorigenesis risk associated with pluripotent stem cells.

Summary:

This review summarizes the progress of iPS cell research in the field of cell therapy.
It examines novel iPS cell technologies and their therapeutic potential.
Strategies for minimizing the risk of tumorigenesis from iPS cell transplantation are discussed.

Impact:

iPS cells represent a promising source for cell therapy in intractable diseases.
Overcoming tumorigenesis risks is crucial for the clinical application of iPS cell-derived tissues.
This research paves the way for safer and more effective stem cell therapies.