Related Experiment Video
Updated: May 25, 2026
09:01
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
Published on: September 27, 2013
[Therapeutic angiogenesis by stem cell transplantation]
Wataru Shioyama1, Issei Komuro
1Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 17, 2012
Summary
Peripheral arterial disease (PAD) treatment needs new options as many patients resist revascularization. Cell therapy shows promise, with angiogenic cytokines like IL-1beta potentially driving therapeutic neovascularization in ischemic limbs.
Area of Science:
- Cardiovascular Medicine
- Regenerative Medicine
- Cell Biology
Context:
- Peripheral arterial disease (PAD) prevalence is rising due to lifestyle factors.
- A significant portion of PAD patients are ineligible for traditional revascularization procedures.
- Endothelial progenitor cells (EPCs) and bone-marrow derived stem cells offer potential for cell-based therapeutic angiogenesis.
Purpose:
- To investigate the underlying mechanisms of cell therapy in treating tissue ischemia.
- To identify key factors associated with therapeutic response in cell-based treatments for PAD.
Summary:
- This study explored the role of angiogenic cytokines in cell therapy for ischemic tissues.
- Results indicate a strong association between angiogenic cytokines, particularly IL-1beta, and treatment response.
- Evidence suggests native muscle cells, rather than implanted cells, are the primary source of these cytokines in ischemic limbs.
Impact:
- The findings shed light on the mechanism of cell therapy-induced neovascularization in PAD.
- Identifies IL-1beta as a crucial mediator in the angiogenic response to cell therapy.
- Suggests a potential therapeutic target for enhancing neovascularization in ischemic conditions.
Related Concept Videos
01:10Mechanism of Angiogenesis
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...