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Updated: May 25, 2026
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
Protective effects of Ginkgo biloba extract on ligature-induced periodontitis in rats
Ufuk Sezer1, Muhammet İsa Kara, Kamile Ercıyas
1Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey. ufuxezer@yahoo.com
Objective:
The aim of this study was to test the hypothesis that the systemic administration of extract of Ginkgo biloba (EGb) would prevent excessive tissue destruction in ligature-induced periodontitis in a rat model.
Materials And Methods:
Thirty-two male Wistar albino rats were used in the current study. The rats were randomly divided into four groups of eight rats each: (1) non-ligated treatment (NL) group, (2) ligature-only (LO) group, (3) ligature plus GB28 (28 mg/kg, daily for 11 days) group and (4) ligature plus GB56 (56 mg/kg, daily for 11 days) group.
Results:
Measurement of alveolar bone loss in the mandibular molar tooth revealed significantly lower bone loss values in the LO group compared to groups NL, GB28 and GB56 (p < 0.05).
Conclusion:
The present results are the first data which suggests that host response in periodontitis can be modified by EGb administration. EGb minimized progression of periodontal disease.
