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Can chlorpromazine prevent flap necrosis?
H D Höft1, P Oswald, A Tilgner
1Department of Maxillo-Facial Surgery and Plastic Surgery, Friedrich Schiller University, Jena, German Democratic Republic.
British Journal of Plastic Surgery
|September 1, 1990
Abstract:
The influence of chlorpromazine hydrochloride on failing, cranially-based dorsal flaps of female rats (Uje:WIST) was studied. The drug was injected subcutaneously into the abdomen pre- and postoperatively. The dosage was 1.5 mg/100 g preoperatively and 0.75 mg/100 g body weight every 12 hours following flap replantation for 10 consecutive days. No improvement in the survival rate was achieved by administration of chlorpromazine hydrochloride in this rat strain.