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Eosinophilic esophagitis: diagnosis and management
Jay A Lieberman1, Mirna Chehade
1Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Immunology and Allergy Clinics of North America
|January 17, 2012
Summary
Eosinophilic esophagitis, a condition involving eosinophil buildup in the esophagus, can be managed with dietary changes and corticosteroids. Allergists and gastroenterologists should be aware of its diagnosis and treatment.
Area of Science:
- Gastroenterology
- Immunology
- Allergy
Background:
- Eosinophilic esophagitis is a clinicopathologic condition characterized by eosinophil infiltration of the esophagus.
- It often presents with upper gastrointestinal symptoms and specific endoscopic findings.
- An atopic background and T-helper type 2 immune response are frequently observed in patients.
Purpose of the Study:
- To review the clinical characteristics of eosinophilic esophagitis.
- To discuss the endoscopic and histologic findings associated with the disease.
- To outline available therapeutic options for eosinophilic esophagitis.
Main Methods:
- This is a review article, synthesizing existing knowledge on eosinophilic esophagitis.
- Information was gathered on clinical presentation, diagnostic criteria, and treatment modalities.
- The review focuses on dietary restrictions, corticosteroids (systemic and topical), and their efficacy.
Main Results:
- Eosinophilic esophagitis presents with diverse upper gastrointestinal symptoms.
- Diagnosis is confirmed by significant esophageal eosinophil infiltration.
- Dietary restriction and corticosteroid therapies demonstrate clinical and histologic resolution.
Conclusions:
- Eosinophilic esophagitis requires familiarity with its diagnosis and management among allergists and gastroenterologists.
- Therapeutic strategies include dietary modifications and corticosteroid treatments.
- Understanding the T-helper type 2 pathogenesis is crucial for effective management.
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