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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

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[Kidney diseases: new issues].

Pierre Ronco1

  • 1Inserm UMRS702, Tenon Hospital, UPMC université Paris 6, 75970 Paris cedex 20, France. pierreronco@yahoo.fr

Presse Medicale (Paris, France : 1983)
|January 17, 2012
PubMed
Summary
This summary is machine-generated.

Millions in France have undiagnosed chronic kidney disease (CKD), a major risk for heart problems. Early screening and new treatments are crucial to manage kidney function and reduce cardiovascular risk.

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Area of Science:

  • Nephrology
  • Epidemiology
  • Cardiology

Context:

  • Chronic kidney disease (CKD) affects 2-4 million people in France, with many unaware of their condition.
  • CKD is a significant independent risk factor for cardiovascular mortality and morbidity, escalating with renal failure severity.
  • Current evaluation of glomerular filtration rate (GFR) uses MDRD and CKD-EPI equations.

Purpose:

  • To advance understanding of CKD epidemiology, risk factors, progression mechanisms, and medical practices.
  • To improve early screening for CKD in high-risk populations (diabetes, hypertension, cardiovascular diseases).
  • To identify novel therapeutic targets and biomarkers for early intervention and halting CKD progression.

Summary:

  • The French CKD-REIN cohort study follows over 3000 patients for 5 years to investigate CKD.
  • Focus on improving screening via blood pressure, proteinuria, and serum creatinine measurements.
  • Aims to discover new treatments to prevent renal insufficiency and decrease cardiovascular risk.

Impact:

  • Enhance knowledge of CKD's burden and progression in France.
  • Facilitate earlier detection and intervention, potentially reducing cardiovascular complications.
  • Inform development of new therapeutic strategies and patient education for better management of kidney disease.