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[Kidney diseases: new issues]

Pierre Ronco1

  • 1Inserm UMRS702, Tenon Hospital, UPMC université Paris 6, 75970 Paris cedex 20, France. pierreronco@yahoo.fr

Presse Medicale (Paris, France : 1983)
|January 17, 2012
PubMed

Insights

Millions in France have undiagnosed chronic kidney disease (CKD), a major risk for heart problems. Early screening and new treatments are crucial to manage kidney function and reduce cardiovascular risk.

Area of Science:

  • Nephrology
  • Epidemiology
  • Cardiology

Context:

  • Chronic kidney disease (CKD) affects 2-4 million people in France, with many unaware of their condition.
  • CKD is a significant independent risk factor for cardiovascular mortality and morbidity, escalating with renal failure severity.
  • Current evaluation of glomerular filtration rate (GFR) uses MDRD and CKD-EPI equations.

Purpose:

  • To advance understanding of CKD epidemiology, risk factors, progression mechanisms, and medical practices.
  • To improve early screening for CKD in high-risk populations (diabetes, hypertension, cardiovascular diseases).
  • To identify novel therapeutic targets and biomarkers for early intervention and halting CKD progression.

Summary:

  • The French CKD-REIN cohort study follows over 3000 patients for 5 years to investigate CKD.
  • Focus on improving screening via blood pressure, proteinuria, and serum creatinine measurements.
  • Aims to discover new treatments to prevent renal insufficiency and decrease cardiovascular risk.

Impact:

  • Enhance knowledge of CKD's burden and progression in France.
  • Facilitate earlier detection and intervention, potentially reducing cardiovascular complications.
  • Inform development of new therapeutic strategies and patient education for better management of kidney disease.

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