Related Experiment Video
Updated: May 25, 2026
09:58
Transplantation of Adipose Tissue-Derived Stem Cell Sheet to Reduce Leakage After Partial Colectomy in A Rat Model
Published on: August 11, 2018
Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model
M Lalountas1, K D Ballas, A Michalakis
1Laboratory of Scientific Research and Experimental Surgery, Second Propedeutical Department of Surgery, Medical School, Aristotle University, and Hippokration General Hospital, Thessaloniki, Greece. miltiadislalountas@yahoo.gr
The British Journal of Surgery
|January 17, 2012
Summary
Statofilm, a novel antiadhesive film, significantly reduced postoperative adhesions in rats compared to Seprafilm®. Low-dose Statofilm demonstrated superior adhesion prevention, suggesting clinical potential.
Area of Science:
- Biomedical Engineering
- Surgical Innovation
- Adhesion Prevention Research
Background:
- Intraperitoneal adhesions are a frequent complication following abdominal surgery.
- Developing effective adhesion barriers is crucial for improving surgical outcomes.
- Statofilm is a new antiadhesive film composed of cross-linked carboxymethylcellulose and atorvastatin.
Purpose of the Study:
- To compare the efficacy of Statofilm against Seprafilm® in preventing postoperative intraperitoneal adhesions.
- To evaluate the dose-dependent effect of atorvastatin in Statofilm on adhesion formation.
- To assess the histological impact of the antiadhesive films on peritoneal tissue.
Main Methods:
- A rat model of induced intraperitoneal adhesions via cecal abrasion was utilized.
- Animals were divided into five groups: control, Seprafilm®, placebo film, low-dose Statofilm, and high-dose Statofilm.
- Adhesion severity was assessed macroscopically and histologically (fibrosis, inflammation, vascularization) two weeks post-surgery.
Main Results:
- All tested antiadhesive films, including Seprafilm®, placebo, and both doses of Statofilm, significantly reduced adhesions compared to the control group.
- Low-dose Statofilm demonstrated superior adhesion prevention compared to Seprafilm® (P = 0.001).
- Adhesion incidence was markedly lower in the low-dose Statofilm group (one-quarter of rats) versus the Seprafilm® group (three-quarters of rats).
Conclusions:
- The novel adhesion barrier, Statofilm, exhibits superior performance over Seprafilm® in preventing postoperative adhesions in a rat model.
- Statofilm, particularly at a low atorvastatin dose, shows promise for future clinical evaluation in preventing surgical adhesions.
- Atorvastatin-containing carboxymethylcellulose films represent a potential advancement in adhesion barrier technology.
