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Updated: May 25, 2026

Following Cell-fate in E. coli After Infection by Phage Lambda
Published on: October 14, 2011
Bubblegrams reveal the inner body of bacteriophage φKZ
Weimin Wu1, Julie A Thomas, Naiqian Cheng
1Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA.
Abstract:
Dense packing of macromolecules in cellular compartments and higher-order assemblies makes it difficult to pick out even quite large components in electron micrographs, despite nominally high resolution. Immunogold labeling and histochemical procedures offer ways to map certain components but are limited in their applicability. Here, we present a differential mapping procedure, based on the physical principle of protein's greater sensitivity to radiation damage compared with that of nucleic acid.
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