Related Experiment Video

Updated: May 25, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Granulomatous myositis associated with brucellosis: a case report and literature review

Suleiman Kojan1, Adel Alothman, Ziad Althani

  • 1College of Medicine, King Saud bin Abdulaziz University, Riyadh 11481, Saudi Arabia. smkojan@yahoo.com

Muscle & Nerve
|January 17, 2012
PubMed

Insights

Brucellosis can cause myositis, a rare muscle inflammation. This case highlights a 16-year-old boy with Brucellosis-associated myositis, emphasizing its extreme rarity and diagnostic considerations.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Rheumatology

Background:

  • Brucellosis is a global public health concern, presenting as a multisystemic infectious disease.
  • Neurobrucellosis affects approximately 4% of brucellosis patients.
  • Brucellosis-associated myositis is exceptionally rare, with limited documented cases.

Observation:

  • A 16-year-old male presented with subacute, fluctuating muscle pain, tenderness, swelling, and asymmetric weakness.
  • Elevated serum Brucella titers were detected in the patient.
  • Muscle biopsy revealed inflammatory granulomatous myositis.

Findings:

  • The case presented is the second reported instance of Brucellosis-associated myositis in English literature.
  • The patient's symptoms and biopsy findings confirmed inflammatory granulomatous myositis linked to Brucellosis.
  • Literature review on myositis associated with Brucellosis was conducted.

Implications:

  • This case underscores the importance of considering Brucellosis in the differential diagnosis of myositis, even in its rare presentations.
  • Early diagnosis and treatment of Brucellosis-associated myositis are crucial for patient outcomes.
  • Further research is warranted to understand the pathogenesis and prevalence of Brucellosis-induced myositis.

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories: