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Updated: May 25, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine
Debanjan Sen1, Anirban Banerjee, Ashoke Kumar Ghosh
1Bengal Institute of Pharmaceutical Sciences, Kalyani, Nadia, West Bengal, India.
Abstract:
A series of 2-substituted and 2,3-substituted quinazolin -4(3H)-one derivatives were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by spectral analysis. The in vivo biological activity test results indicated that those compounds exhibited antimalarial activities against Plasmodium berghei in mice, at a dose of 5 mg/kg. Compared to Chloroquine and Artemisinin, these compounds have the advantages of shorter synthetic routes and consequently are highly cost effective in nature.
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