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Updated: May 23, 2026
Detection of Protein Palmitoylation in Cultured Hippocampal Neurons by Immunoprecipitation and Acyl-Biotin Exchange (ABE)
Published on: February 18, 2013
Engineering NRas palmitoylation to hook zDHHC inhibitors
Mitra S Rana1, Anirban Banerjee1
1Section on Structural and Chemical Biology, Eunice Kennedy Shriver National Institute of Child Health and Development (NICHD), National Institutes of Health, Bethesda, MD 20892, USA.
Abstract:
Protein palmitoylation is an important lipidic post-translation modification catalyzed by the zDHHC protein acyltransferases. In this issue of Cell Chemical Biology, Zhu et al.1 use an imaginative approach to control NRas palmitoylation and use it as a platform to identify inhibitors of protein palmitoylation.
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