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Published on: December 8, 2017
Cell-surface glycoRNAs put the brakes on neuroinflammation
1Institute of Modern Biology, Nanjing University, Nanjing, China.
Abstract:
Cell-surface glycoRNAs are emerging as neuroimmune signals. In this issue of Cell Chemical Biology, Wang et al. showed in co-culture that neuronal glycoRNAs engaged microglial Siglec-11, increased SHP1 phosphorylation, suppressed NF-κB-dependent cytokine production, and improved neuronal-cell survival, establishing signaling direction, downstream mechanism, and protective function for a glycoRNA-Siglec pathway.1.
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