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Yin Yang 1 in human cancer
Sarah Nicholson1, Helen Whitehouse, Khimara Naidoo
1Department of Histopathology, Manchester Royal Infirmary, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester, United Kingdom.
Critical Reviews in Oncogenesis
|January 18, 2012
Summary
The transcription factor Yin Yang 1 (YY1) regulates cell proliferation and apoptosis, crucial in cancer development. Its role in tumor progression is complex and debated, with conflicting associations with patient outcomes across various cancers.
Area of Science:
- Oncology
- Molecular Biology
- Gene Regulation
Background:
- The transcription factor Yin Yang 1 (YY1) is a key regulator of cellular processes like proliferation and apoptosis.
- YY1's expression is observed across numerous human cancers, including breast, prostate, colon, and brain cancers, as well as leukemias and sarcomas.
- YY1 influences the expression of genes involved in cell cycle control and apoptosis, acting as both an activator and repressor.
Purpose of the Study:
- To review the literature on the role of Yin Yang 1 (YY1) in human tumorigenesis.
- To provide an overview of the increasingly recognized importance of YY1 in the development and progression of various human cancers.
- To highlight the controversial prognostic significance of YY1 due to conflicting associations with patient outcomes.
Main Methods:
- Literature review of studies investigating Yin Yang 1 (YY1) expression and function in human cancers.
- Analysis of research associating YY1 with cancer development, tumor progression, metastasis, and survival.
- Synthesis of data on the prognostic significance of YY1 in different cancer types.
Main Results:
- YY1 expression is linked to the development of malignant phenotypes, tumor progression, and survival in some human cancers.
- Conflicting data exists regarding YY1's prognostic significance, with studies reporting both favorable and unfavorable associations with patient outcomes.
- The diverse roles of YY1 in controlling proliferation and apoptosis likely contribute to its varied impact on different tumor types.
Conclusions:
- Yin Yang 1 (YY1) plays a significant, albeit complex and context-dependent, role in human tumorigenesis.
- The dual functions of YY1 in cell proliferation and apoptosis contribute to its controversial prognostic value in cancer.
- Further research is needed to elucidate the precise mechanisms by which YY1 influences cancer progression and patient outcomes across different malignancies.
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