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Updated: May 25, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals
09:31

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

Influenza virus resistance to neuraminidase inhibitors: implications for treatment

Shivanjali Shankaran1, Gonzalo M L Bearman

  • 1Hunter Holmes McGuire VA Medical Center, 1201 Broad rock Boulevard, Richmond, VA, 23249, USA, shivanjali.shankaran@gmail.com.

Current Infectious Disease Reports
|January 18, 2012
PubMed

Insights

Oseltamivir resistance is a growing concern in influenza treatment, particularly for immunocompromised patients. Alternative antivirals, vaccination, and combination therapies may be necessary for effective influenza management.

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Oseltamivir and Zanamivir are key neuraminidase inhibitors for influenza treatment.
  • Emerging oseltamivir resistance is documented in various influenza strains, including pandemic H1N1.
  • This resistance correlates with increased patient morbidity and adverse outcomes, especially in immunocompromised individuals.

Purpose of the Study:

  • To highlight the clinical significance of oseltamivir resistance in influenza.
  • To explore potential alternative treatment strategies for influenza in the context of antiviral resistance.

Main Methods:

  • Review of current literature on neuraminidase inhibitors and influenza resistance.
  • Analysis of clinical outcomes associated with oseltamivir resistance.
  • Evaluation of alternative therapeutic approaches.

Main Results:

  • Oseltamivir resistance is a documented challenge in managing influenza infections.
  • Severely immunocompromised patients with resistant influenza strains experience poorer outcomes.
  • Emerging resistance necessitates exploring alternative treatment options.

Conclusions:

  • The rise of oseltamivir-resistant influenza poses a significant clinical challenge.
  • Alternative neuraminidase inhibitors, enhanced vaccination strategies, and combination therapies are promising alternatives.
  • Proactive management strategies are crucial for combating influenza, especially in vulnerable populations.

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